Wednesday 24 June 2026

Time	Session/Location
08:00 - 09:00	ISHR-INT Council Meeting - Room 202
08:00 - 09:00	Registration and Refreshments - Foyers of Teaching and Learning Building
09:00 - 09:55	Plenary Session 3 - Lecture Theatre 1 Keith Reimer Lecture Professor Mike Murphy, University of Cambridge, UK Session Chair: Sean Davidson, University College London, UK
09:55 - 10:00	2026 Distinguished Leader Award Thomas Eschenhagen, University Medical Center Hamburg Eppendorf, Germany Session Chair: Sean Davidson, University College London, UK
10:00 - 10:30	ISHR General Assembly - Lecture Theatre 1
10:30 - 11:00	Refreshment Break - Foyers of Teaching and Learning Building
	Lecture Theatre 1 - Teaching and Learning Building	Lecture Theatre 2 - Teaching and Learning Building	G15 - Muirhead Tower
11:00 - 12:30	Session 16 Pathophysiological and Molecular Mechanisms of Cardiac Aging Invited Speakers: (20 minutes each) Ippei Shimizu, National Cerebral and Cardiovascular Center, Japan Ageing and senescence what is the difference? Yohan Santin, Monzino Cardiology Center, Italy Lysosomal alkanylisation: a new driver of cardiomyocyte senescence Jeanne Mialet-Perez, Mitolab, Inserm1083-cnrs6015, France Mitochondrial dynamics in cardiac aging Selected Abstracts: (15 minutes each) O31 - Ezechiel Agbegbo, I2MC, University of Toulouse, INSERM, UMR-1297, France cAMP nuclear signalosome promotes senescence and inflammation during cardiac aging O32 - Jose Sanchez-Alonso, Imperial College London, National Heart & Lung Institute, UK Innervation remodels cardiomyocyte excitation–contraction coupling, ion channel organisation, and protects against senescence-associated dysfunction Session Chairs: Frank Lezoualc’h, University of Toulouse, France Serena Zacchigna, International Centre for Genetic Engineering and Biotechnology (ICGEB), Italy	Session 17 Mitochondria in Cardiovascular Disease Invited Speakers: (20 minutes each) John Elrod, Lewis Katz School of Medicine At Temple University, United States Discovery of an Integrated Signaling System Regulating Ca2+-Dependent Mitochondrial Metabolons Paulus Kirchhof, University Medical Center Hamburg-Eppendorf, Germany Atrial metabolic defects: Genetic predisposition and relation to atrial fibrillation Martina Semenzato, University of Padova, Italy Opa1 in the heart: a role in autophagy Selected Abstracts: (15 minutes each) O33 - Tibor Maske Pressure overload-induced mitochondrial oxidative stress impairs cardiac energetics and drives right ventricular failure O34 - Sarah-Lena Puhl Mitochondrial reactive oxygen species determine murine macrophage responses to pressure-overload Session Chairs: Asa Gustafsson, University of Padova, Italy Nina Kaludercic, University of Padova, Italy	Session 18 The Vascular side of Heart Failure Invited Speakers: (20 minutes each) Stéphane Germain, College de France, France ANGPTL4, a multifaceted protein at the cross-talk between metabolism and cardiovascular disorders Mairi Brittan, University of Edinburgh, UK Mapping the developing human cardiac endothelium at single-cell resolution Jaap van Buul, Amsterdam Umc, Netherlands  Inflammation in the heart: How leukocytes extravasate the circulation Selected Abstracts: (15 minutes each) O35 - Manon Restituito, Avignon University, Avignon, France Interplay between O-GlcNAcylation and phosphorylation of endothelial NO synthase: consequences on vascular stress response O36 - Tian Lan, Heidelberg University, Germany Endothelin-1 signaling regulates chamber-specific mouse atrial cardiomyocyte cytokinesis and polyploidy Session Chairs: Ines Falcao-Pires, University of Porto, Portugal  Niels Voigt, University Medical Center Göttingen, Germany
12:30 - 14:00	Lunch and Poster Session 4 - (Room 118/119)
13:00 - 14:00	Meet the Editors - Lecture Theatre 2 David Eisner, University of Manchester, UK (Editor-in-Chief - Journal of General Physiology) Gregory Lim, Nature Reviews Cardiology, UK (Chief Editor -Nature Reviews Cardiology) Elisa Martini, Nature Cardiovascular Research, Italy (Senior Editor - Nature Cardiovascular Research) Davor Pavlovic, University of Birmingham, UK (Editor-in-Chief - JMCC Plus) Dario Ummarino, SpringerNature, UK (Senior Editor - Communications Biology)
	Lecture Theatre 1 - Teaching and Learning Building	Lecture Theatre 2 - Teaching and Learning Building	G15 - Muirhead Tower
14:00 - 15:30	Session 19 Cardiovascular Impact of New Antidiabetic Drugs: Mechanisms and Clinical Translation Invited Speakers: (20 minutes each) Viktória Tóth, Semmelweis University, Hungary GLP-1 from bench to bedside Panagiota Efstathia Nikolaou, National and Kapodistrian University of Athens, Greece Cardioprotective Mechanisms of SGLT2 Inhibitors: Beyond Glycaemia David Lefer, Smidt Heart Institute, Cedars Sinai, USA  SGLT2i mechanisms of actions in HF Selected Abstracts: (15 minutes each) O37 - Mengnan Wang, University of Amsterdam, Netherland GLP-1 receptor agonist Semaglutide mitigates disturbed flow-induced oxidative stress through NCX inhibition in human coronary artery endothelial cells, independent of GLP-1 receptor O38 - Mert Ozhan, Ege University Faculty of Pharmacy, Turkey Modulatory Effects of Empagliflozin on Endogenous Hydrogen Sulfide Production in a Rat Model of Diabetic Cardiomyopathy Session Chairs: Christoph Maack, University Hopsital Würzburg, Germany Dunja Aksentijevic, Queen Mary University London, UK	Session 20 Bioengineering and Organoids in Cardiovascular Disease Invited Speakers: (20 minutes each) Katrin Streckfuss-Bömeke, University Clinic Würzburg, Germany Optimizing metabolic and electrical maturation in iPSC and cardiac organoids Filipo Perbellini, King's College London, UK Living myocardial slices as Heart Disease Model Serena Zacchigna, ICGEB and University of Trieste, Italy Mechanical load as a disease-modifying signal: insights from engineered heart tissues Selected Abstracts: (15 minutes each) O39 - Camilla Olianti, King's College London, UK Morpho-functional characterization of RNAi-induced cardiac regeneration O40 - Federica D'Ettorre, University of Padua, Italy Patient-specific iPSC-derived cardiac microtissues capture early molecular and cellular changes in Friedreich’s Ataxia cardiomyopathy Session Chairs: Katja Gehmlich, University of Birmingham, UK Jean-Sebastian Hulot, Paris Cardiovascular Research Center, France	Session 21 Ca Channel Chit Chat in CM Pathophysiology Invited Speakers: (20 minutes each) Christian Soeller, University of Bern, Switzerland Ryr clustering and calcium microdomains - analysed by minflux super resolution microscopy Leonardo Sacconi, Institute of Clinical Physiology (IFC) - CNR, Italy Cardiac Fibrosis and Arrhythmias Cristina Molina, University Medical Center Hamburg-Eppendorf, Germany Neuronal regulation of Ca²⁺ release in human myocytes via cAMP signalling Selected Abstracts: (15 minutes each) O41 - Shuai Luo, Inserm U1180, Orsay, France Pro-Arrhythmic Mechanisms of the RyR2-C2277R Mutation in CPVT Revealed by Patient-Derived iPSC-Cardiomyocytes O42 - Funsho Emmanuel Fakuade, Georg-August University Göttingen, Germany Increased intracellular calcium buffering promotes atrial arrhythmogenesis in heart failure with reduced ejection fraction Session Chairs: Delphine Mika, University of Paris-Sud 11 UMR-S 1180, France Ana-Maria Gomez, University of Paris-Sud 11 UMR-S 1180, France
15:30 - 16:00	Refreshment Break - Foyers of Teaching and Learning Building