Wednesday 24 June 2026
| Time | Session/Location | |||
|---|---|---|---|---|
| 08:00 - 09:00 | ISHR-INT Council Meeting - Room 202 |
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| 08:00 - 09:00 | Registration and Refreshments - Foyers of Teaching and Learning Building | |||
| 09:00 - 10:00 |
Plenary Session 3 - Lecture Theatre 1 Professor Mike Murphy (University of Cambridge) Keith Reimer Lecture |
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| 10:00 - 10:30 | ISHR General Assembly - Lecture Theatre 1 | |||
| 10:30 - 11:00 | Refreshment Break - Foyers of Teaching and Learning Building | |||
| Lecture Theatre 1 - Teaching and Learning Building |
Lecture Theatre 2 - Teaching and Learning Building |
G15 - Muirhead Tower |
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| 11:00 - 12:30 | Session 16 Pathophysiological and Molecular Mechanisms of Cardiac Aging Invited Speakers: (20 minutes each) Ippei Shimizu Ageing and senescence what is the difference? Yohan Santin Lysosomal alkanylisation: a new driver of cardiomyocyte senescence Jeanne Mialet-Perez Mitochondrial dynamics in cardiac aging Selected Abstracts: (15 minutes each) Ezechiel Agbegbo cAMP nuclear signalosome promotes senescence and inflammation during cardiac aging Jose Sanchez-Alonso Innervation remodels cardiomyocyte excitation–contraction coupling, ion channel organisation, and protects against senescence-associated dysfunction Session Chairs: Frank Lezoualc’h Serena Zacchigna |
Session 17 Mitochondria in Cardiovascular Disease Invited Speakers: (20 minutes each) John Elrod Discovery of an Integrated Signaling System Regulating Ca2+-Dependent Mitochondrial Metabolons Aleksandra Trifunovic Mitochondrial stress signals and unexpected cellular adaptations Martina Semenzato Opa1 in the heart: a role in autophagy Selected Abstracts: (15 minutes each) Tibor Maske Pressure overload-induced mitochondrial oxidative stress impairs cardiac energetics and drives right ventricular failure Sarah-Lena Puhl Mitochondrial reactive oxygen species determine murine macrophage responses to pressure-overload Session Chairs: Asa Gustafsson Nina Kaludercic |
Session 18 The Vascular side of Heart Failure Invited Speakers: (20 minutes each) Stéphane Germain ANGPTL4, a multifaceted protein at the cross-talk between metabolism and cardiovascular disorders Mairi Brittan Mapping the developing human cardiac endothelium at single-cell resolution Jaap van Buul Inflammation in the heart: How leukocytes extravasate the circulation Selected Abstracts: (15 minutes each) Manon Restituito Interplay between O-GlcNAcylation and phosphorylation of endothelial NO synthase: consequences on vascular stress response Tian Lan Endothelin-1 signaling regulates chamber-specific mouse atrial cardiomyocyte cytokinesis and polyploidy Session Chairs: Niels Voigt |
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| 12:30 - 14:00 | Lunch and Poster Session 4 | |||
| 13:00 - 14:00 | Meet the Editors - Lecture Theatre 2 | |||
| Lecture Theatre 1 - Teaching and Learning Building |
Lecture Theatre 2 - Teaching and Learning Building |
G15 - Muirhead Tower |
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| 14:00 - 15:30 |
Session 19 Cardiovascular Impact of New Antidiabetic Drugs: Mechanisms and Clinical Translation Invited Speakers: (20 minutes each) Viktória E Tóth GLP-1 from bench to bedside Panagiota Efstathia Nikolaou Cardioprotective Mechanisms of SGLT2 Inhibitors: Beyond Glycaemia David Lefer SGLT2i mechanisms of actions in HF Selected Abstracts: (15 minutes each) Mengnan Wang GLP-1 receptor agonist Semaglutide mitigates disturbed flow-induced oxidative stress through NCX inhibition in human coronary artery endothelial cells, independent of GLP-1 receptor Mert Ozhan Modulatory Effects of Empagliflozin on Endogenous Hydrogen Sulfide Production in a Rat Model of Diabetic Cardiomyopathy Session Chairs: Christoph Maack Dunja Aksentijevic |
Session 20 Bioengineering and Organoids in Cardiovascular Disease Invited Speakers: (20 minutes each) Katrin Streckfuss-Bömeke Optimizing metabolic and electrical maturation in iPSC and cardiac organoids Filipo Perbellini Living myocardial slices as Heart Disease Model Twan de Vries Deciphering arrhythmias using human preclinical models Selected Abstracts: (15 minutes each) Camilla Olianti Morpho-functional characterization of RNAi-induced cardiac regeneration Federica D'Ettorre Patient-specific iPSC-derived cardiac microtissues capture early molecular and cellular changes in Friedreich’s Ataxia cardiomyopathy Session Chairs: Katja Gehmlich Jean-Sebastian Hulot |
Session 21 Ca Channel Chit Chat in CM Pathophysiology Invited Speakers: (20 minutes each) Christian Soeller Ryr clustering and calcium microdomains - analysed by minflux super resolution microscopy Leonardo Sacconi Calcium dynamics - from the sub cellular to the tissue level Cristina Molina Ca2+ release control by cAMP microdomains Selected Abstracts: (15 minutes each) Shuai Luo Pro-Arrhythmic Mechanisms of the RyR2-C2277R Mutation in CPVT Revealed by Patient-Derived iPSC-Cardiomyocytes Funsho Emmanuel Fakuade Increased intracellular calcium buffering promotes atrial arrhythmogenesis in heart failure with reduced ejection fraction Session Chairs: Delphine Mika Ana-Maria Gomez |
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| 15:30 - 16:00 | Refreshment Break - Foyers of Teaching and Learning Building | |||
As part of the organisation of this conference, The University of Birmingham's Event Management Team is collecting income via registration fees and sponsorships on behalf of theInternational Society for Heart Research, European Section (ISHR-ES)