CONFERENCE PROGRAMME

Thursday 11th September

08:30 - 09:30	REGISTRATION & ARRIVAL REFRESHMENTS
09:30 - 09:50	Welcome & Introduction
SESSION 1: CHROMATIN
09:50 - 10:30	Brad Cairns - Widespread Transient Activation of ERVs in Cleavage-Stage Embryos Involves the Conversion of the Repressor SETDB1 to a Co-Activator by RHOX12L
10:30 - 10:45	O1 - Karen Lane - Multi-omic profiling following loss of SWI/SNF chromatin remodelling complexes reveals global changes in cohesin binding and sensitivity to cohesin perturbation
10:45 - 11:00	O2 - Paul Badenhorst - Combinatorial histone modifications direct ATP-dependent chromatin remodeling by NURF to promoter proximal nucleosomes
11:00 - 11:20	REFRESHMENT BREAK
11:20 - 11:40	Andrew Bowman - Dynamic long-range movement of megabase-sized heterochromatin domains in living cells
11:40 - 12:00	Nitika Taneja - Mechanisms of Chromatin Re-organization upon Replication Stress
12:00 - 12:10	Covaris - Sponsor Talk
12:10 - 12:20	New England Biolabs - Sponsor Talk
12:20 - 12:50	Flash Talks (2 minutes per talk) Chongluan Shi - Investigating the regulation of E3 ubiquitin ligase TRAIP in DNA replication Gemma Regan-Mochrie - Histone H4R3C: A new oncohistone that drives genomic instability Alice Ormrod - The radiobiological impact of protons in combination with DNA double strand break repair inhibitors in glioblastoma models Rosa Camarillo Daza - The where, when and how of DNA repair in quiescent cells Panagiotis Kotsantis - RNF169 is implicated in the DNA replication stress response Elizabeth Anthony and Ruth Densham - Using a BRCA1/BARD1 gap-suppression separation of function mutant to elucidate mechanisms of therapy responses Maryam Eftekharifar - Deciphering cell-type specific inter-chromosomal genome architecture via single-cell Hi-C and machine learning Tom Wright - Combining Genome Engineering with Next-Generation Sequencing to Unravel the Functions of the NuRD Complex Yagiz Ozturk - Ctdp1, a phosphatase at the intersection of transcription and cell viability Alexander Lanz - SUMOylation promotes mitotic DNA damage repair Adedoyin Adeyemi - Exploring the link between Transcription and Translation in Fission Yeast Luis Padilla-Cortes - Structural characterization of SPEN’s IDR and its role the formation of gene silencing supramolecular complexes Akhil Bowry - The 7SK small nuclear ribonucleoprotein marries the cell responses to both transcriptional and replication stress by promoting homologous recombination and replication fork reversal
12:50 - 14:20	LUNCH & POSTER SESSION 1 - ODD POSTER NUMBERS
SESSION 2: REPLICATION AND DAMAGE
14:20 - 14:40	Vincenzo Costanzo - Unraveling the role of homologous recombination proteins in Vertebrate DNA replication
14:40 - 15:00	Michiel Vermeulen - Deciphering gene expression regulation in health and disease using proximity labeling
15:00 - 15:15	O3 - Alicja Reynolds-Winczura - CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS
15:15 - 15:30	O4 - Yara Aghabi - Cyclin F: A novel BRCA2 interactor with impacts on replication fidelity
15:30 - 15:50	REFRESHMENT BREAK
SESSION 3: REPLICATION AND DAMAGE
15:50 - 16:10	Massimo Lopes - Replication fork plasticity in cancer and stem cells
16:10 - 16:30	Evi Soutouglou - DNA damage at Lamina Associated Domains triggers nuclear envelope reorganization and chromatin detachment to prevent nuclear envelope blebbing and genome instability
16:30 - 16:45	O5 - Richard Kelly - Coordinated Activation of RAS and PI3K Signalling Drives Oncogene-Induced Replication Stress via Hypertranscription
16:45	CONFERENCE CLOSE
BRYAN TURNER'S RETIREMENT PARTY - GISBERT KAPP BUILDING - ROOM NG16
17:00 - 18:00	Bryan Turner
18:00 - 19:00	DRINKS RECEPTION - EDGBASTON PARK HOTEL, LLOYD SUITE LOUNGE
19:00 - LATE	DINNER - EDGBASTON PARK HOTEL, LLOYD SUITE

Friday 12th September

08:30 - 09:00	REGISTRATION & ARRIVAL REFRESHMENTS
SESSION 4: CHROMATIN
09:00 - 09:20	Tineke Lenstra - Understanding transcription factor search, one molecule at a time
09:20 - 09:40	Wendy Bickmore - Beyond the tail: acetylation of the histone globular domain marks fragile nucleosomes at key regulatory sites
09:40 - 10:00	O6 - Nicolae Radu Zabet - Explainable Artificial Intelligence identifies novel mammalian enhancers and their epigenetic code
10:00 - 10:15	O7 - Colin Hammond - Exploring the role of heat shock molecular chaperones during histone supply and deposition
10:15 - 10:30	O8 - Robert Turnbull - Rapid degradation of six class 1 HDAC complexes reveals minimal functional overlap and unique functions for each complex
10:30 - 10:50	REFRESHMENT BREAK
10:50 - 11:10	Monika Gullerova - The role of RNA modifications in DNA damage response
11:10 - 11:30	Thomas Schalch - The HMD domain of the PAF complex primes Rad6-Bre1 E3 ligase complexes for H2B ubiquitination
11:30 - 11:45	O9 - Isabel Díez Santos - Understanding the role of senataxin in the resolution of transcription-replication conflicts
11:45 - 11:55	Parse Biosciences - Sponsor talk
11:55 - 12:25	Flash Talks (2 minutes per talk) Nagham Ghadder - The impact of the SWI/SNF complex subunit ARID1A on the chromatin environment surrounding stalled replication forks Eduardo De La Vega - Unbiased detection of replication initiation events in human cells using BrdU incorporation and single-molecule nanopore sequencing Maria Rita Fabbrizi - Understanding the cellular DNA damage response in head and neck cancer cells treated with Boron Neutron Capture Therapy Emily Prowse - Inhibition of PRMT5-mediated arginine methylation decreases Ewing sarcoma (ES) survival in an EWSR1-ETS-dependent manner by inducing DNA damage Olga Brieieva - The lysine methyltransferase SETD1A promotes ssDNA gaps formation under replication stress Kristupas Sirvydis - XIST supercomplexes- key actors in X-inactivation during early human embryonic development Ammarah Tariq - Structure and Regulation of the H2B E3 Ligase Complex Paolo Passaretti - The Structure of the Xenopus laevis Replisome Rosanna Wilkins - Upregulation of human RNase H2 counteracts replication stress elicited by oncogenes and chemotherapy drugs Panagiotis Patsis - Dissecting the regulatory mechanisms governing the histone 3 lysine 9 methyltransferase Clr4
12:25 - 14:00	LUNCH & POSTER SESSION 2 - EVEN POSTER NUMBERS
SESSION 5: TRANSCRIPTION REGULATION
14:00 - 14:20	Jorge Ferrer - A transcription-splicing axis as a therapeutic target for diabetes mellitus
14:20 - 14:40	Anne Ferguson-Smith - Mammalian retrotransposon-mediated genetic and epigenetic variation
14:40 - 15:00	Chris Lord - Resistance to treatment in HRD breast cancers
15:00 - 15:15	O10 - Kelly Chiang - Targeting PRMT5-mediated splicing: A new therapeutic opportunity for triple negative breast cancers
15:15 - 15:30	O11 - Naomi Eastwood - The chromatin remodeller ARID1A functions through FOX and AP-2 transcription factors in lobular breast cancers
15:30 - 15:55	REFRESHMENT BREAK
SESSION 6: TRANSCRIPTION REGULATION
15:55 - 16:15	Alex Stark - Decoding transcriptional regulation
16:15 - 16:30	O12 - Nicoletta Bobola - Ubiquitous transcription factors MEIS actuate lineage-specific transcription to establish cell fate
16:30 - 16:45	O13 - Michael Tellier - NELF prevents genomic instability by regulating RNA polymerase II transcription elongation and termination
16:45 - 17:00	PRIZES & CONFERENCE CLOSE