Rémi Grégoire graduated in 1986 from the École Centrale de Nantes, where he specialised in naval engineering. He then obtained a postgraduate diploma (DEA) in fluid dynamics from the Polytechnic Institute of Grenoble. He began his career as a hydrodynamicist, before moving across to the rail sector, initially working for SNCF, before moving to Alstom Transport in 2002, as the head of the key competencies network in aerodynamics. He currently works at Alstom's headquarters in Saint-Ouen, France, as part of the "AeroX" team, bringing his aerodynamic expertise and innovative solutions to all types of train and rail system projects.

Throughout his career, Rémi has supported the development of international standards for railway aerodynamics, having led various work packages on national and multi-national projects, such as TRANSAERO. He has also overseen the successful achievement of aerodynamic requirements for the introduction of numerous trains into traffic across France and Europe. From 2005 to 2007, in close collaboration with his counterpart at SNCF, he participated in the development of all aerodynamic studies related to the V150 project; this project resulted in a new world speed record on rail in April 2007 (575 km/h).

Finally, Rémi Grégoire provides internal training in aerodynamics for young engineers joining Alstom. For the past 15 years, he has also enthusiastically taught railway aerodynamics courses to final-year students at ESTACA (an engineering school located in Saint-Quentin-en-Yvelines, near Paris), who are preparing to work with various players in the global railway industry.